Harnessing the gut microbiome in the fight against anthelminthic drug resistance

Industry in the fight against COVID-19 crisis

Harnessing the power of the human microbiome.

S ince the earliest days of microbiology, it has been clear that all humans carry many of the same microbial lineages. We now call the collection of microbes living in or on our bodies the human microbiome (1), and a large international effort, called the Human Microbiome Project (HMP) by the National Institutes of Health (2), and known more broadly as the International Human Microbiome Consort...

Nanoantibiotics: strategic assets in the fight against drug-resistant superbugs

Antimicrobial characteristics of metals reveal that Ag despite its economic constraints remains the most popular antibiotic agent. Antimicrobial characteristics of copper nanoparticles (CNPs) are not well understood. To our knowledge, no systematic comparative study on microbial properties of silver nanoparticles (SNPs) and CNPs exists. In this article, a comparative study on microbial properti...

Antibiotic resistance potential of the healthy preterm infant gut microbiome

BACKGROUND Few studies have investigated the gut microbiome of infants, fewer still preterm infants. In this study we sought to quantify and interrogate the resistome within a cohort of premature infants using shotgun metagenomic sequencing. We describe the gut microbiomes from preterm but healthy infants, characterising the taxonomic diversity identified and frequency of antibiotic resistance ...

Mining the human gut microbiome for novel stress resistance genes

With the rapid advances in sequencing technologies in recent years, the human genome is now considered incomplete without the complementing microbiome, which outnumbers human genes by a factor of one hundred. The human microbiome, and more specifically the gut microbiome, has received considerable attention and research efforts over the past decade. Many studies have identified and quantified "...